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Indeed, PTE is a debilitating condition characterized by recurrent seizures that develop as a consequence of brain injury and is considered one of the most devastating long‐term complications of TBI [232, 233]

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[99] It has been suggested that the relative affinity of dsDNA antibodies from SLE patients for LJP-394 may impact their responses to the drug, and patients with high-affinity antibodies to LJP-394 experience a reduction in affinity after four months of weekly treatment